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The Rice
laboratory isolated the first infectious clone of HCV (Kolykhalov
et al., Science 277, 570-574, 1997). The commercial rights
to this technology, including
U.S. 6,127,116, are exclusively licensed to Apath from
Washington University, and is available for nonexclusive
license to the field.
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Infectious HCV RNA from cDNA
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Potential uses of infectious HCV
molecular clone
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Screen for permissive cell cultures
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Genetic analysis of HCV replication/pathogenesis
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Standardized/engineered HCV
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Screen for alternative animal models
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